Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain
作者： Chia-Shan Wu , Christopher P Jew , Hui-Chen Lu
DOI: 10.2217/FNL.11.27
关键词: Cannabinoid 、 Cannabis 、 Neuroscience 、 Cognition 、 Cannabinoid receptor 、 Endocannabinoid system 、 Illicit Substance 、 Neurogenesis 、 Animal studies 、 Medicine
摘要: Cannabis is the most commonly used illicit substance among pregnant women. Human epidemiological and animal studies have found that prenatal cannabis exposure influences brain development can long-lasting impacts on cognitive functions. Exploration of therapeutic potential cannabis-based medicines synthetic cannabinoid compounds has given us much insight into physiological roles endogenous ligands (endocannabinoids) their receptors. In this article, we examine human longitudinal cohort document long-term influence to cannabis, followed by an overview molecular composition endocannabinoid system temporal spatial changes in expression during development. How signaling modulates fundamental developmental processes such as cell proliferation, neurogenesis, migration axonal pathfinding are also summarized.
sci-hub.se 参考文章(155)
M. Sabrina Spano, Maria Ellgren, X. Wang, Yasmin L. Hurd, Prenatal Cannabis Exposure Increases Heroin Seeking with Allostatic Changes in Limbic Enkephalin Systems in Adulthood Biological Psychiatry. ,vol. 61, pp. 554- 563 ,(2007) , 10.1016/J.BIOPSYCH.2006.03.073
David Baker, Gareth Pryce, Wayne L. Davies, C. Robin Hiley, In silico patent searching reveals a new cannabinoid receptor. Trends in Pharmacological Sciences. ,vol. 27, pp. 1- 4 ,(2006) , 10.1016/J.TIPS.2005.11.003
P. Berghuis, A. M. Rajnicek, Y. M. Morozov, R. A. Ross, J. Mulder, G. M. Urban, K. Monory, G. Marsicano, M. Matteoli, A. Canty, A. J. Irving, I. Katona, Y. Yanagawa, P. Rakic, B. Lutz, K. Mackie, T. Harkany, Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science. ,vol. 316, pp. 1212- 1216 ,(2007) , 10.1126/SCIENCE.1137406
Oscar Marín, John L. R. Rubenstein, A long, remarkable journey: Tangential migration in the telencephalon Nature Reviews Neuroscience. ,vol. 2, pp. 780- 790 ,(2001) , 10.1038/35097509
Benjamin F Cravatt, Aron H Lichtman, Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system Current Opinion in Chemical Biology. ,vol. 7, pp. 469- 475 ,(2003) , 10.1016/S1367-5931(03)00079-6
Gale A Richardson, Christopher Ryan, Jennifer Willford, Nancy L Day, Lidush Goldschmidt, Prenatal alcohol and marijuana exposure: Effects on neuropsychological outcomes at 10 years Neurotoxicology and Teratology. ,vol. 24, pp. 309- 320 ,(2002) , 10.1016/S0892-0362(02)00193-9
James B Aimone, Wei Deng, Fred H Gage, None, Adult neurogenesis: integrating theories and separating functions Trends in Cognitive Sciences. ,vol. 14, pp. 325- 337 ,(2010) , 10.1016/J.TICS.2010.04.003
Gale A. Richardson, Nancy L. Day, Lidush Goldschmidt, Prenatal alcohol, marijuana, and tobacco use: Infant mental and motor development Neurotoxicology and Teratology. ,vol. 17, pp. 479- 487 ,(1995) , 10.1016/0892-0362(95)00006-D
Miriam Schneider, Cannabis use in pregnancy and early life and its consequences: animal models European Archives of Psychiatry and Clinical Neuroscience. ,vol. 259, pp. 383- 393 ,(2009) , 10.1007/S00406-009-0026-0
Anja C. Huizink, Moderate use of alcohol, tobacco and cannabis during pregnancy: new approaches and update on research findings Reproductive Toxicology. ,vol. 28, pp. 143- 151 ,(2009) , 10.1016/J.REPROTOX.2009.04.010