IGF signalling in germ cells and testicular germ cell tumours: roles and therapeutic approaches.

摘要: The insulin-like growth factor (IGF) axis plays key roles in normal tissue and development as well the progression of several tumour types their subsequent to a metastatic phenotype. This review explores role IGF system germ cell function addition examining evidence for deregulation signalling cancer, with particular relevance supporting testicular tumours (TGCTs). Despite clear preclinical rationale targeting there has been lack progress identifying which patients may benefit from such therapy. Future employment agents pathway is expected concentrate on use combination other treatments prevent resistance exploit potential chemo- radiosensitizers.