Cargo transport: molecular motors navigate a complex cytoskeleton.
作者： Jennifer L Ross , M Yusuf Ali , David M Warshaw
DOI: 10.1016/J.CEB.2007.11.006
关键词: Cytoplasmic dynein 、 Cytoskeleton 、 Molecular motor 、 Biology 、 Kinesin 、 Microtubule 、 Cytoskeletal Filaments 、 Cell biology 、 Biophysics 、 Actin 、 Myosin
摘要: Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, the actin-based myosin motors to maneuver through challenges presented by filamentous meshwork that comprises cytoskeleton. Recent in vitro single molecule biophysical studies have begun explore this process characterizing what occurs as these tiny molecular happen upon an intersection between two cytoskeletal filaments. These studies, combination with vivo work, define mechanism which exchange while traveling tracks deliver it its destination when going from cell center periphery back again.
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