The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction.

摘要: BACKGROUND: Carvedilol is a nonselective β-adrenoceptor and selective α 1 -adrenoceptor blocker widely used in the treatment of patients with hypertensive and/or chronic heart failure because, unlike classic β-blockers, this drug has additional endothelium-dependent vasodilatory effects. We evaluated effects oral administration carvedilol on cardiopulmonary resuscitation (CPR) rat model cardiac arrest (CA) induced by airway obstruction. METHODS: Twenty-four rats were randomly assigned to 2 groups: control group (no medication) (oral [10 mg/kg/d] for 5 days) (n = 12 per group). All animals anesthetized, CA was obstructing airway. Three minutes after CA, revived administering CPR. The rate chest compressions (CCs) 240 260 CCs/min depth CCs adjusted maintain diastolic arterial blood pressure between 25 30 mm Hg both groups. Epinephrine (0.02 mg/kg) administered No other therapy before, during, or CA. RESULTS: time interval obstruction significantly longer than (230 ± 27 vs 203 24 seconds; P < 0.05). return spontaneous circulation higher (92% 50%; Acidosis increased glucose tumor necrosis factor-α concentrations lower group. CONCLUSIONS: results our study showed that had been several days more resistant obstruction, when did occur, likely be resuscitated. These findings suggest may prolong safe ischemic respiratory failure.