Prediction of transient ischemic attack and minor stroke in people with type 2 diabetes mellitus.

摘要: Abstract Aims People with type 2 diabetes (T2DM) have an increased risk of transient ischemic attack and minor stroke (TIA) which are frequently followed by stroke. We aimed to develop a predictive model for incident TIA in people T2DM. Methods pooled data from two longitudinal cohort studies, Atherosclerosis Risk Communities (ARIC) the Cardiovascular Health Study (CHS), using two-stage approach. First, we used random effects interpolate factors individuals between follow-up exams. Second, forward selection proportional hazards time TIA. internally validated our 10-fold cross-validation. Results Among 3,575 participants T2DM, mean (SD) age was 60 (10) years body mass index 30 (6) kg/m2. Sixty-nine TIAs occurred during 38,364 person-years follow-up. The multivariable included at diagnosis (hazard ratio 1.13 (95% confidence interval: 1.05,1.21) per year), systolic blood pressure (1.25 (1.04,1.49) 10 mmHg), quadratic function diastolic pressure, history congestive heart failure (2.08 (1.26, 3.42)). median cross-validated Harrell’s C-index 0.80. Conclusion Blood earliest stages cerebrovascular disease.