Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop.

摘要: There is an increased need to develop novel alternative approaches the two-year rodent bioassay for carcinogenicity assessment of substances where still a basic requirement, as well those animal use banned or limited information gaps are identified within legislation. The current progress in this area was addressed EURL ECVAM- ESTIV workshop held October 2016, Juan les Pins. A number initiatives were presented and discussed, including data-driven, technology-driven pathway-driven approaches. Despite seemingly diverse range strategic developments, commonalities emerging. For example, providing insight into mechanisms becoming increasingly appreciated aspect hazard suggested be best strategy drive new developments. Thus, now more than ever, there combine focus efforts towards integration available between sectors. Such cross-sectorial harmonisation will aid building confidence approach methods leading implementation thus decreased necessity bioassay.