Serum Cystatin C, enzymuria, tubular proteinuria and early renal insult in type 2 diabetes.

摘要: This study investigates the association between serum cystatin C, creatinine concentrations, N-acetyl-beta-D-glucosaminidase (NAG enzymuria), urine alpha1-microglobulin (alpha1-MG) and beta2-microglobulin (beta2-MG) levels in subjects with type 2 diabetes (n=40, 20M/20F, age range 25-65 years; duration of 8-10 years) age- gender-matched healthy controls (n= 20). Exclusion criteria were absence gross proteinuria, hypertension, dyslipidaemia or cardiovascular disease. Fasting blood samples mid-stream specimen (MSSU) collected creatinine, NAG enzymuria, alpha1-MG beta2-MG measured. Diabetic separated into two groups based on albumin:creatinine concentration ratio. Group A: <3.5 (mg/mmol creatinine), group B: 3.5-35 creatinine). While concentrations remained within laboratory reference for all groups, C (mg/L) was significantly increased B (1.79 +/- 0.42 [mean SD] compared to both control [0.81 0.10] A values [0.95 0.10]; P<0.001). enzymuria (units/mmol creatinine) diabetic (group 122 7, 70 5, 27 2, (microg/mmol similar diabetics at 1.10 0.10 1.11 0.21, respectively, elevated 2.10 0.41 (both P<0.01). Similarly, also observed (3.20 0.21 vs. 1.80 0.51 0.91 0.11, respectively; In addition, higher than (P<0.001). These observations suggest that is a more appropriate effective biomarker overall estimation GFR values. associated early renal tubular insult diabetes, as characterised by alpha1- excretion.