Blood Vessel Network Remodeling During Tumor Growth

摘要: With the help of a theoretical model process in which growing tumor transforms hierarchically organized arterio-venous blood vessel network into specific vasculature is analyzed. The determinants this remodeling involve morphological and hydrodynamic properties initial network, generation new vessels (sprouting angiogenesis), dilation (circumferential growth), flow correlated regression, cell proliferation death, interdependence these processes via spatio-temporal changes parameters, oxygen/nutrient supply growth factor concentration fields. emerging nonhierarchical, compartmentalized well characterized zones, displays complex geometry with necrotic zones “hot spots” increased vascular density varying size, transports drug injections efficiently. Implications for current views on tumor-induced angiogenesis are discussed.