The presence of 1-naphthol in the urine of industrial workers exposed to naphthalene.
作者： G Bieniek
DOI: 10.1136/OEM.51.5.357
关键词: Occupational exposure 、 Toxicokinetics 、 Urine 、 Naphthalene 、 1-Naphthol 、 Work shift 、 Excretion 、 Chemistry 、 Chromatography
摘要: 1-Naphthol at concentrations ranging from 0.4 to 34.6 mg/l was found in urine collected directly after the end of work shift a group industrial workers employed distillation naphthalene oil. The maximum excretion one hour and mean rate 0.57 mg/h. Coke plant exposed other aromatic polycyclic hydrocarbons also had 1-naphthol their urine. Mean values were 0.89 (working with new technology) 4.86 old rates 0.19 0.31 mg/h respectively. shifted two three hours exposure. For non-exposed subjects urinary concentration 120 micrograms/l 7.0 micrograms/h.
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sci-hub.se 参考文章(8)
J. K. Piotrowski, Evaluation of exposure to phenol: absorption of phenol vapour in the lungs and through the skin and excretion of phenol in urine Occupational and Environmental Medicine. ,vol. 28, pp. 172- 178 ,(1971) , 10.1136/OEM.28.2.172
Jerzy Piotrowski, The Application of Metabolic and Excretion Kinetics to Problems of Industrial Toxicology Occupational and Environmental Medicine. ,vol. 29, pp. 345- 346 ,(1972) , 10.1136/OEM.29.3.345-B
Jeffrey E. Keiser, Kenneth W. Kirby, Fred Tremmel, Reversed-phase high-performance liquid chromatographic separation of human phenolic metabolites of propoxur (Baygon), carbofuran and carbaryl Journal of Chromatography A. ,vol. 259, pp. 186- 188 ,(1983) , 10.1016/S0021-9673(01)87995-4
W.H. Chern, W.C. Dauterman, Studies on the metabolism and excretion of 1-naphthol, 1-naphthyl-β-d-glucuronide, and 1-naphthyl-β-d-glucoside in the mouse Toxicology and Applied Pharmacology. ,vol. 67, pp. 303- 309 ,(1983) , 10.1016/0041-008X(83)90313-7
H. R. Sanborn, D. C. Malins, The disposition of aromatic hydrocarbons in adult spot shrimp (Pandalus platyceros) and the formation of metabolites of naphthalene in adult and larval spot shrimp. Xenobiotica. ,vol. 10, pp. 193- 200 ,(1980) , 10.3109/00498258009033745
Larry M. Tremaine, Gary L. Diamond, Aloysius J. Quebbemann, In vivo quantification of renal glucuronide and sulfate conjugation of 1-naphthol and p-nitrophenol in the rat. Biochemical Pharmacology. ,vol. 33, pp. 419- 427 ,(1984) , 10.1016/0006-2952(84)90235-1
F A Redegeld, G A Hofman, J Noordhoek, Conjugative clearance of 1-naphthol and disposition of its glucuronide and sulfate conjugates in the isolated perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics. ,vol. 244, pp. 263- 267 ,(1988)
Pieroń G, Kustra G, Bocheńska T, Skorek R, Rózańska R, Jabłońska E, Bieniek G, Czogała J, Levels of metabolites of selected chemical compounds in the urine of workers in pitch coke plant Medycyna Pracy. ,vol. 40, pp. 183- 191 ,(1989)