2H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc.
作者： William Perea , Marco Cannella , Jun Yang , Alexander J. Vega , Tatyana Polenova
DOI: 10.1002/MRM.21231
关键词: Nuclear magnetic resonance 、 Tissue Degeneration 、 Nucleus 、 Deuterium 、 Double quantum 、 Intervertebral disc 、 Relaxation (NMR) 、 Water dynamics 、 Chemistry 、 Nuclear magnetic resonance spectroscopy
摘要: Deuterium (2H) double-quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build-up rates, and DQF-detected rotating-frame spin-lattice relaxation times are sensitive to the degree hydration NP tissue, display a monotonous correlation with age between 15 80 years. implications this work that changes in water dynamics as detected via may be used probe tissue degeneration NP, particularly early stages which most standard methods not sensitive. Magn Reson Med 57:990 –999, 2007.
sci-hub.se 参考文章(35)
Victor Haughton, P. A. Anderson, J. Fine, C. Mistretta, Y. Wu, J. Perry, The value of T2 relaxation times to characterize lumbar intervertebral disks: preliminary results. American Journal of Neuroradiology. ,vol. 27, pp. 337- 342 ,(2006)
U. Eliav, G. Navon, Quadrupole-echo techniques in multiple-quantum-filtered NMR spectroscopy of heterogeneous systems Journal of Magnetic Resonance, Series A. ,vol. 115, pp. 241- 253 ,(1995) , 10.1006/JMRA.1995.1173
Yaniv Assaf, Gil Navon, Yoram Cohen, In vivo observation of anisotropic motion of brain water using 2H double quantum filtered NMR spectroscopy Magnetic Resonance in Medicine. ,vol. 37, pp. 197- 203 ,(1997) , 10.1002/MRM.1910370210
Norbert Boos, Daniel Dreier, Esther Hilfiker, Volker Schade, Roland Kreis, Josef Hora, Max Aebi, Chris Boesch, Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative magnetic resonance imaging. Journal of Orthopaedic Research. ,vol. 15, pp. 141- 149 ,(1997) , 10.1002/JOR.1100150121
Kazuya Ikoma, Yoshiaki Kusaka, Hisatake Takamiya, Uzi Eliav, Gil Navon, Yoshiteru Seo, Evaluation of collagen fiber maturation and ordering in regenerating tendons employing H-1 double quantum filtered NMR spectroscopy. Journal of Orthopaedic Research. ,vol. 21, pp. 149- 156 ,(2003) , 10.1016/S0736-0266(02)00092-X
Kayvan R. Keshari, Jeffrey C. Lotz, John Kurhanewicz, Sharmila Majumdar, Correlation of HR-MAS Spectroscopy Derived Metabolite Concentrations With Collagen and Proteoglycan Levels and Thompson Grade in the Degenerative Disc Spine. ,vol. 30, pp. 2683- 2688 ,(2005) , 10.1097/01.BRS.0000188256.88859.9C
Hadassah Shinar, Yoshiteru Seo, Gil Navon, Discrimination between the Different Compartments in Sciatic Nerve by2H Double-Quantum-Filtered NMR Journal of Magnetic Resonance. ,vol. 129, pp. 98- 104 ,(1997) , 10.1006/JMRE.1997.1250
Victor Haughton, Medical Imaging of Intervertebral Disc Degeneration : Current Status of Imaging Spine. ,vol. 29, pp. 2751- 2756 ,(2004) , 10.1097/01.BRS.0000148475.04738.73
Teresa Nightingale, Alex MacKay, Richard H. Pearce, Kenneth P. Whittall, Borys Flak, A model of unloaded human intervertebral disk based on NMR relaxation. Magnetic Resonance in Medicine. ,vol. 43, pp. 34- 44 ,(2000) , 10.1002/(SICI)1522-2594(200001)43:1<34::AID-MRM5>3.0.CO;2-7
Gil Navon, Hadassah Shinar, Uzi Eliav, Yoshiteru Seo, Multiquantum filters and order in tissues. NMR in Biomedicine. ,vol. 14, pp. 112- 132 ,(2001) , 10.1002/NBM.687