Lithium and tricyclic antidepressants.

摘要: Pharmacokinetic studies of lithium and tricyclic antidepressants (TCAs) in children adolescents report similarities to adults with respect a wide interindividual genetic variation the rate elimination regard linear nature system. Children may eliminate these medications more rapidly; therefore, frequent dosing be necessary maintain steady state serum or plasma TCA levels. Doses for desired blood levels can obtained from tables based on nomograms (i.e., one-step dosage adjustment determined single level drawn 24 hours after administration dose). Use dose prediction avoids toxicity due excessively high genetically slow metabolizers whom medication regimes that use mg/kg schedules produce toxic