Rebamipide Promotes the Regeneration of Aspirin-Induced Small-Intestine Mucosal Injury through Accumulation of β-Catenin
作者： Yu Lai , Wa Zhong , Tao Yu , Zhong-Sheng Xia , Jie-Yao Li
DOI: 10.1371/JOURNAL.PONE.0132031
关键词: Immunology 、 Tight junction 、 Rebamipide 、 Small intestine 、 Regeneration (biology) 、 Cancer research 、 Jejunum 、 Intestinal mucosa 、 Biology 、 Catenin 、 Intestinal absorption 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background The effect of rebamipide on repairing intestinal mucosal damage induced by nonsteroidal anti-inflammatory drugs and its mechanism remain unclear. In this study, we sought to explore the whereby could promote regeneration aspirin-induced damage.
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Y Doki, M Monden, Y Kimura, M Hirao, M Furuse, H Shiozaki, S Tsukita, T Monden, Y Maeno, Y Ando-Akatsuka, M Inoue, Expression of occludin, tight-junction-associated protein, in human digestive tract. American Journal of Pathology. ,vol. 151, pp. 45- 54 ,(1997)
Xiao-Qing Sun, Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats World Journal of Gastroenterology. ,vol. 7, pp. 555- 558 ,(2001) , 10.3748/WJG.V7.I4.555
Tarnawski A, Yoshikawa T, Kobayashi K, Arakawa T, Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Digestive Diseases and Sciences. ,vol. 43, ,(1998)
U Haglund, G B Bulkley, P O Park, K Fält, The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion. Surgery. ,vol. 107, pp. 574- 580 ,(1990)
Kikuko Amagase, Nahoko Izumi, Yuka Takahira, Tomoko Wada, Koji Takeuchi, Importance of cyclooxygenase-1/prostacyclin in modulating gastric mucosal integrity under stress conditions. Journal of Gastroenterology and Hepatology. ,vol. 29, pp. 3- 10 ,(2014) , 10.1111/JGH.12767
Osamu Tetsu, Frank McCormick, Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. ,vol. 398, pp. 422- 426 ,(1999) , 10.1038/18884
Akiko Shiotani, Takashi Sakakibara, Maki Nomura, Yoshiyuki Yamanaka, Ryuji Nishi, Hiroshi Imamura, Ken-ichi Tarumi, Tomoari Kamada, Jiro Hata, Ken Haruma, Aspirin-induced peptic ulcer and genetic polymorphisms Journal of Gastroenterology and Hepatology. ,vol. 25, ,(2010) , 10.1111/J.1440-1746.2009.06212.X
Shinya Kishimoto, Ken Haruma, Akira Tari, Kazushi Sakurai, Minoru Nakano, Yasushi Nakagawa, Rebamipide, an antiulcer drug, prevents DSS-induced colitis formation in rats. Digestive Diseases and Sciences. ,vol. 45, pp. 1608- 1616 ,(2000) , 10.1023/A:1005525313856
Koji Takeuchi, Shinichi Kato, Kikuko Amagase, Prostaglandin EP Receptors Involved in Modulating Gastrointestinal Mucosal Integrity Journal of Pharmacological Sciences. ,vol. 114, pp. 248- 261 ,(2010) , 10.1254/JPHS.10R06CR
Richard B. Brandt, Stephen A. Siegel, Michael G. Waters, Michael H. Bloch, Spectrophotometric assay for d-(−)-lactate in plasma Analytical Biochemistry. ,vol. 102, pp. 39- 46 ,(1980) , 10.1016/0003-2697(80)90314-0