Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study.

摘要: With population aging, prevalence of low bone mineral density (BMD) and associated fracture risk are increased. To determine whether circulating thyroid stimulating hormone (TSH) levels within the normal range causally related to BMD, we conducted a two-sample Mendelian randomization (MR) study. Furthermore, tested common genetic variants in TSH receptor (TSHR) gene influencing expression TSHR (expression quantitative trait loci [eQTLs]) with BMD. For both analyses, used summary-level data genomewide association studies (GWASs) investigating BMD femoral neck (n = 32,735) lumbar spine 28,498) cohorts European ancestry from Genetic Factors Osteoporosis (GEFOS) Consortium. MR study, selected 20 that were previously identified for GWAS meta-analysis 26,420). All independent instruments combined analyses In these studies, found no evidence genetically determined 1-standard deviation (SD) decrease concentration was (0.003 SD per TSH; 95% CI, -0.053 0.048; p 0.92) or (0.010 -0.069 0.049; 0.73). A total 706 have been mapped locus TSHR. However, none at spine. conclusion, causal effect on nor did find any between variation thereof © 2018 The Authors. Journal Bone Mineral Research Published by WileyPeriodicals, Inc.