Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects.

摘要: There is evidence that oat β-glucan lowers appetite and ad libitum eating; however, not all studies are consistent, the underpinning mechanisms entirely understood. We investigated effects of 4 g high molecular weight (MW) on eating, subjective appetite, glycemia, insulinemia plasma GLP-1 responses in 33 normal-weight subjects (22 female/11 male, mean age (y): 26.9 ± 1.0, BMI (kg/m2): 23.5 ± 0.4). The study followed a randomised double-blind, cross-over design with fed two test breakfasts without by an meal different days. Blood samples ratings for were collected postprandially at regular time intervals. Oat increased feelings fullness (p = 0.048) satiety (p = 0.034), but did affect energy amount eaten meal. was treatment interaction GLP-1, insulin blood glucose. significantly reduced 90 min (p = 0.021), glucose 30 min (p = 0.008) 30 60 min (p = 0.002 0.017, respectively) following breakfast when compared control breakfast. Four grams MW eating beneficially modulates postprandial glycaemia, it does increase secretion.