Accelerated Partial Breast Irradiation Using Only Intraoperative Electron Radiation Therapy in Early Stage Breast Cancer
作者： Sergio Maluta , Stefano Dall'Oglio , Nadia Marciai , Milena Gabbani , Zeno Franchini
DOI: 10.1016/J.IJROBP.2012.03.013
关键词: Sentinel node 、 Mastectomy 、 Radiation therapy 、 Partial Breast Irradiation 、 Surgery 、 Intraoperative electron radiation therapy 、 Radiology 、 Breast cancer 、 Medicine 、 Whole Breast Irradiation 、 Breast surgery
摘要: Background We report the results of a single-institution, phase II trial accelerated partial breast irradiation (APBI) using single dose intraoperative electron radiation therapy (IOERT) in patients with low-risk early stage cancer. Methods and Materials A cohort 226 low-risk, cancer were treated local excision axillary management (sentinel node biopsy or without dissection). After surgeon temporarily reapproximated cavity, 21 Gy IOERT was delivered to tumor bed, margin 2 cm laterally. Results With mean follow-up 46 months (range, 28-63 months), only 1 case recurrence reported. The observed toxicity considered acceptable. Conclusions APBI can be safely women early, carefully selected patients. longer is needed ascertain its efficacy compared that current standard treatment whole-breast irradiation.
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