Cimetidine in Anesthesia: Does it Minimize the Complications of Acid Aspiration?

摘要: The use of cimetidine, an H2-receptor antagonist, to minimize the complications acid aspiration pneumonia is reviewed. Since Mendelson's early description in 66 obstetrical patients, attempts have been made decrease gastric acidity by administering perioperative antacids and/or antihistamine drugs such as atropine and glycopyrrolate. In this review literature, strict attention given study design subject selection, methods collecting samples reporting both pH volume measurements, medications taken on admission, preoperatively, anesthetics. Clinical trials evaluating cimetidine alone compared with other prophylactic regimens were reviewed, detailing timing, route, frequency drug administration. Cimetidine appears be effective minimizing since (pH less than 2.5) a contributing factor morbidity mortality disease state. general terms, 300 mg po 1.5-2.0 h prior intubation or 45-60 minutes iv before surgery will below critical level. This effect may maintained for up three hours. Perioperative administration, aspiration, safe terms drug-drug interactions effects labor, fetus, newborn child.