Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use

摘要: BackgroundRodent paradigms and human genome-wide association studies (GWASs) on drug use have the potential to provide biological insight into pathophysiology of addiction. MethodsUsing GeneWeaver, we created rodent alcohol nicotine gene-sets derived from 19 gene expression outcomes. We partitioned SNP-heritability these using four large GWASs: 1) alcoholic drinks per week, 2) problematic use, 3) cigarettes day 4) smoking cessation. benchmarked our findings with curated alcoholism addiction performed specificity analyses other (e.g., locomotor behavior) GWASs height). ResultsThe gene-set was enriched for heritability day, cessation, but not use. However, significantly associated any traits. Both showed enrichment several non-substance GWASs, extent this relationship tended increase as a function trait heritability. In general, larger demonstrated more significant enrichment. Finally, when evaluating traits similar heritabilities, both greater substance ConclusionOur results suggest that can help identify genes capture in humans, yet less than expected due various factors such genetic architecture trait. outline limitations, interpretations considerations future research.