Ovarian-cell-like cells from skin stem cells restored estradiol production and estrus cycling in ovariectomized mice.
作者： Bong-Wook Park , Bo Pan , Derek Toms , Evanna Huynh , June-Ho Byun
关键词: Biology 、 Internal medicine 、 Ovary 、 Endocrinology 、 Cellular differentiation 、 Stem cell 、 Estrous cycle 、 Transplantation 、 Somatic cell 、 Follicle-stimulating hormone 、 Ovarian follicle
摘要: Reduction of estradiol production and high serum concentrations follicular stimulating hormone (FSH) are endocrine disorders associated with premature ovarian failure. Here, we report that transplantation ovarian-like cells differentiated from stem restored endogenous levels. Stem were isolated postnatal mouse skin into ovarian-cell-like consistent female germ, follicle somatic cells. The transplanted ovariectomized mice (Cell Trans), whereas control subjected to bilateral ovariectomies without cell (OVX). Using vaginal cytology analysis, it was revealed in 13 out 19 Cell Trans mice, estrus cycles around 8 weeks after maintained until 16 post-transplantation, the OVX group, all arrested at metestrus/diestrus cycle. uterine weight group simil...
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