Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction.
作者： Kathrin Schömig , Gabriele Busch , Birgit Steppich , Dominik Sepp , Jan Kaufmann
关键词: Progenitor cell 、 Vascular endothelial growth factor 、 Vascular endothelial growth factor A 、 Interleukin 、 Interleukin 8 、 Endothelium 、 Cancer research 、 Medicine 、 Stem cell 、 Immunology 、 Cytokine
摘要: Aims Release of progenitor cells is observed during inflammatory conditions and contributes to neovascularization. We, therefore, sought investigate the relationship circulating interleukin (IL)-8 in acute myocardial infarction (AMI). Methods results From patients with stable angina AMI, serial venous blood samples were obtained. The number CD133+CD45− cells, endothelial (EPCs), P1H12+CD45− was analyzed by flow cytometry. After stenting an increase plasma IL-8 vascular growth factor (VEGF) concentrations observed, which only minimal angina. Only this followed cells. In contrast, E-selectin RNA expression peripheral elevated early indicating shedding activated Multivariable analysis revealed association addition statin therapy risk profile. Conclusion associated pro-angiogenic functions VEGF, mechanism may contribute new vessel generation and, thereby, improve function.
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