Transcription of the human neuronal nitric oxide synthase gene in the central nervous system is mediated by multiple promoters.

摘要: Publisher Summary The principal contribution described in this chapter is the identification and initial characterization of two distinct promoters for human NOS1 gene transcription. Although closely linked, these are separable, that they can independently drive expression appropriately linked reporter genes transfection systems. demonstration independent promoter activities renders it unlikely alternative splicing a single primary transcript produces heterogeneity mRNA structure reflected cDNA clones pNOS5′1 pNOS5′2. number expressing neurons level rise sharply then decline during development chicken tectum. Recent pharmacological studies indicate induction might be crucial to establishing appropriate pattern synaptic connections Moreover tectum appears require projection axons from retinal ganglion cells. Potential mechanisms alterations CNS anticipated emerge through function. It also important characterize genetic basis because apt provide valuable research tool. NOS+ selectively resistant degeneration Huntington's chorea Alzheimer's disease, ischemia, response assaults by neurotoxin quinolinic acid. In addition, dramatically induced spinal motor as well dorsal root ganglia, avulsion proximal transection, respectively.