Somatic Molecular Genetics of Prostate Cancer

摘要: Despite progress in diagnosis and treatment, prostate cancer is still one of the most frequent lethal diseases men Western countries. Today, an increasing number cancers are detected through elevated serum prostate-specific antigen (PSA) levels. PSA detection very sensitive. Determining free versus total level has enabled achievement better specificity (Balk et al. 2003), however, this tool remains imperfect. Many patients undergo unnecessary diagnostic procedures, experiencing physiological psychological stress. Similarly, current techniques such as imaging biopsies not optimal thus, hopes high for discovery new molecular markers cancer. Studying progression may reveal insights into mechanisms development to help improve prevention, provide tools diagnosis, well prognosis treatment.