The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus.
作者： Ingo Bauer , Matthias Misslinger , Yana Shadkchan , Anna-Maria Dietl , Verena Petzer
关键词: Pathogen 、 Biology 、 Aspergillus fumigatus 、 Downregulation and upregulation 、 Virulence 、 Microbiology 、 Gene silencing 、 Gene expression 、 In vivo 、 Xylose
摘要: … Establishing a novel in vivo conditional gene expression system, we demonstrate that downregulation of the class 1 lysine deacetylase (KDAC) RpdA leads to avirulence of A. fumigatus …
frontiersin.org
figshare.com
sci-hub.se 参考文章(60)
G. Pontecorvo, J.A. Roper, L.M. Chemmons, K.D. Macdonald, A.W.J. Bufton, The Genetics of Aspergillus nidulans Advances in Genetics. ,vol. 5, pp. 141- 238 ,(1953) , 10.1016/S0065-2660(08)60408-3
Alexander A. Bachmanov, Danielle R. Reed, Gary K. Beauchamp, Michael G. Tordoff, Food Intake, Water Intake, and Drinking Spout Side Preference of 28 Mouse Strains Behavior Genetics. ,vol. 32, pp. 435- 443 ,(2002) , 10.1023/A:1020884312053
Felicitas Fazius, Ekaterina Shelest, Peter Gebhardt, Matthias Brock, The fungal α‐aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate Molecular Microbiology. ,vol. 86, pp. 1508- 1530 ,(2012) , 10.1111/MMI.12076
Alberto Elías-Villalobos, Alfonso Fernández-Álvarez, Ismael Moreno-Sánchez, Dominique Helmlinger, José I. Ibeas, The Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type Genes PLOS Pathogens. ,vol. 11, pp. e1005134- ,(2015) , 10.1371/JOURNAL.PPAT.1005134
Keith Vogt, Ruchi Bhabhra, Judith C Rhodes, David S Askew, Doxycycline-regulated gene expression in the opportunistic fungal pathogen Aspergillus fumigatus BMC Microbiology. ,vol. 5, pp. 1- 11 ,(2005) , 10.1186/1471-2180-5-1
Chi-Jan Lin, Christoph Sasse, Jennifer Gerke, Oliver Valerius, Henriette Irmer, Holm Frauendorf, Thorsten Heinekamp, Maria Straßburger, Van Tuan Tran, Britta Herzog, Susanna A. Braus-Stromeyer, Gerhard H. Braus, Transcription Factor SomA Is Required for Adhesion, Development and Virulence of the Human Pathogen Aspergillus fumigatus PLOS Pathogens. ,vol. 11, pp. e1005205- ,(2015) , 10.1371/JOURNAL.PPAT.1005205
Hayley E. Bugeja, Michael J. Hynes, Alex Andrianopoulos, HgrA is necessary and sufficient to drive hyphal growth in the dimorphic pathogen Penicillium marneffei Molecular Microbiology. ,vol. 88, pp. 998- 1014 ,(2013) , 10.1111/MMI.12239
Gerald Brosch, Peter Loidl, Stefan Graessle, Histone modifications and chromatin dynamics: a focus on filamentous fungi Fems Microbiology Reviews. ,vol. 32, pp. 409- 439 ,(2008) , 10.1111/J.1574-6976.2007.00100.X
Iliana A. Chatzispyrou, Ntsiki M. Held, Laurent Mouchiroud, Johan Auwerx, Riekelt H. Houtkooper, Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research. Cancer Research. ,vol. 75, pp. 4446- 4449 ,(2015) , 10.1158/0008-5472.CAN-15-1626
Vito Valiante, Thorsten Heinekamp, Radhika Jain, Albert Härtl, Axel A. Brakhage, The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response Fungal Genetics and Biology. ,vol. 45, pp. 618- 627 ,(2008) , 10.1016/J.FGB.2007.09.006