Innate Immunity Under Conditions of Space Flight

摘要: The innate immune system is one of the oldest host defense mechanisms against invading pathogens. Innate cells are able to recognise and phagocytose pathogens activate adaptive through antigen presenting cells. Humans experience alterations under many clinical conditions, which can certain circumstances negatively affect outcome disease states. In space, a highly challenging environment for humans survive in, changes in have been demonstrated but full picture still lacking. From initial observations gathered during Apollo missions it clear that astronauts become more susceptible infection as result spaceflight. More recent investigations reduced reactive oxygen species generation phagocytic abilities attenuated global cellular responses. pathways investigated man space date only just scratched surface antimicrobial armory available system. Although research gold standard, human spaceflight complex mixture stressors, technically financially challenging. Earth-based scenarios models such parabolic flight head down tilt bed rest mimicking short term zero gravity, confinement isolation hostile environments Antarctica, will help elucidate effects specific individual stressors on immunity.