Quercetin nanocomposite as novel anticancer therapeutic: improved efficiency and reduced toxicity.
作者： Giuseppe Cirillo , Orazio Vittorio , Silke Hampel , Francesca Iemma , Paolo Parchi
DOI: 10.1016/J.EJPS.2013.04.008
关键词: DPPH 、 ABTS 、 Antioxidant 、 Nuclear chemistry 、 Nanocomposite 、 Radical polymerization 、 Viability assay 、 Flavonoid 、 Organic chemistry 、 Quercetin 、 Chemistry
摘要: Abstract A three-functional nanocomposite was prepared by radical polymerization of methacrylic acid around carbon nanotubes in the presence Quercetin as biologically active molecule and proposed new anticancer therapeutic. The so-obtained hybrid material characterized FT-IR, Raman, SEM, TEM analyses, while functionalization degree 2.33 mg per g composite assessed Folin–Ciocalteu test. Antioxidant test (DPPH ABTS) showed that covalent coupling did not interfere with antioxidant properties flavonoid, activity greatly enhanced a recorded IC50 value much lower than free Quercetin. Cell viability tests on healthy cells demonstrated no-toxicity conjugate
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