Does the primary site of colorectal cancer impact outcomes for patients with metastatic disease

摘要: BACKGROUND Previous reports have described differences in biology and outcome for colorectal cancer based on whether the primary is right or left sided. Further division by right, left, rectum even exact site has also been explored. Possible response to biological agents reported side of lesion. METHODS We explored South Australian registry metastatic assess if there were any patient characteristics, prognostic markers, treatment received outcomes was We exist colon site. RESULTS Two thousand nine hundred seventy-two patients analyzed. Thirty-five percent had a right-sided primary. The median overall survival entire group versus 9.6 20.3 months (P < .001). Multivariate analysis confirmed as an independent factor. For that active therapy, defined chemotherapy (± metastasis resection), 18.2 months; 29.4 Importantly, we found no suggestion major divided rectum, trends individual still supported division. CONCLUSIONS Patients with more negative factors indeed inferior compared those left-sided Our data further breakdown favor simple left-versus-right moving forward cancer. Cancer 2015;121:830–835. © 2014 American Society.