Effects of GLP-1 and Incretin-Based Therapies on Gastrointestinal Motor Function
作者： Chinmay S. Marathe , Christopher K. Rayner , Karen L. Jones , Michael Horowitz
DOI: 10.1155/2011/279530
关键词: Incretin 、 Gastrointestinal tract 、 Small intestine 、 Internal medicine 、 Endocrinology 、 Biology 、 Pharmacology 、 Glucagon-like peptide-1 、 Postprandial 、 Enterogastrone 、 Gastric acid 、 Enteral administration
摘要: Glucagon-like peptide 1 (GLP-1) is a hormone secreted predominantly by the distal small intestine and colon released in response to enteral nutrient exposure. GLP-1-based therapies are now used widely management of type 2 diabetes have potential be effective antiobesity agents. Although known as an incretin hormone, there growing body evidence that GLP-1 also acts enterogastrone, with profound effects on gastrointestinal motor system. Moreover, motility appear pivotal its effect reducing postprandial glycaemic excursions may, potentially, represent dominant mechanism. This review summarizes current knowledge enterogastrone properties GLP-1, focusing gut at physiological pharmacological concentrations, actions incretin-based therapies. While importance, inhibitory action gastric acid secretion beyond scope this paper.
hindawi.com参考文章(112)
Curt Oehme, Karl Wimmers, Wirkung von Duodenalschleimhautextrakten (Secretin) auf den Blutzucker Research in Experimental Medicine. ,vol. 38, pp. 1- 8 ,(1923) , 10.1007/BF02622931
Sutep Gonlachanvit, Chia-Wen Hsu, Guenther H. Boden, Linda C. Knight, Alan H. Maurer, Robert S. Fisher, Henry P. Parkman, Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients. Digestive Diseases and Sciences. ,vol. 48, pp. 488- 497 ,(2003) , 10.1023/A:1022528414264
A. Amato, L. Cinci, A. Rotondo, R. Serio, M. S. Faussone-pellegrini, M. G. Vannucchi, F. Mulè, Peripheral motor action of glucagon‐like peptide‐1 through enteric neuronal receptors Neurogastroenterology and Motility. ,vol. 22, pp. 664- 672 ,(2010) , 10.1111/J.1365-2982.2010.01476.X
L. Pala, S. Ciani, I. Dicembrini, G. Bardini, B. Cresci, A. Pezzatini, S. Giannini, E. Mannucci, C. M. Rotella, Relationship between GLP-1 levels and dipeptidyl peptidase-4 activity in different glucose tolerance conditions. Diabetic Medicine. ,vol. 27, pp. 691- 695 ,(2010) , 10.1111/J.1464-5491.2010.03010.X
Michael Horowitz, Melvin Samsom, Gastrointestinal function in diabetes mellitus J. Wiley. ,(2004)
Ladislaus Takács, Versuche mit Secretin Research in Experimental Medicine. ,vol. 57, pp. 527- 531 ,(1927) , 10.1007/BF02610248
T. Edholm, M. Degerblad, P. Grybäck, L. Hilsted, J. J. Holst, H. Jacobsson, S. Efendic, P. T. Schmidt, P. M. Hellström, Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis. Neurogastroenterology and Motility. ,vol. 22, pp. 1191- ,(2010) , 10.1111/J.1365-2982.2010.01554.X
Magda Giralt, Glucagonlike peptide-1 (GLP-1) participation in ileal brake induced by intraluminal peptones in rat. Digestive Diseases and Sciences. ,vol. 44, pp. 322- 329 ,(1999) , 10.1023/A:1026654417697
J.N. Hunt, J.L. Smith, C.L. Jiang, Effect of meal volume and energy density on the gastric emptying of carbohydrates. Gastroenterology. ,vol. 89, pp. 1326- 1330 ,(1985) , 10.1016/0016-5085(85)90650-X
S. Guha, M. Horowitz, K.L. Jones, J.M. Wishart, L. Green, B.I. Carney, Gastric Emptying in Early Noninsulin-Dependent Diabetes Mellitus The Journal of Nuclear Medicine. ,vol. 37, pp. 1643- 1648 ,(1996)