Sodium carboxymethylation-functionalized chitosan fibers for cutaneous wound healing application
作者： Dong Yan , Zhong-Zheng Zhou , Chang-Qing Jiang , Xiao-Jie Cheng , Ming Kong
DOI: 10.1007/S11706-016-0353-9
关键词: Nuclear chemistry 、 Absorption of water 、 Polymer chemistry 、 Sodium 、 Materials science 、 Skin repair 、 Biomaterial 、 Wound healing 、 Chitosan 、 Swelling 、 Granulation tissue
摘要: A water absorption biomaterial, sodium carboxymethylation-functionalized chitosan fibers (Na-NOCC fibers) were prepared, applied for cutaneous wound repair, and characterized by FTIR NMR. The of Na-NOCC increased significantly with substitution degree rising, from 3.2 to 6.8 g/g, higher than that (2.2 g/g) confirmed swelling behavior. In the antibacterial action, high exhibited stronger activities against E. coli (from 66.54% up 88.86%). inhibition S. aureus above 90%, more effective coli. cytotoxicity assay demonstrated Na-NOCC2 no obvious mouse fibroblasts. Wound healing test histological examination showed advanced granulation tissue capillary formation in healing-impaired wounds treated fibers, as compared those gauze, which Na- NOCC could promote skin repair might have great application healing.
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