The effect of oxygenation on sleep quality in chronic bronchitis and emphysema

作者: Neil J. Douglas , Peter M. A. Calverley , David C. Flenley , Vlasta Brezinova , James R. Catterall

DOI: 10.1164/ARRD.1982.126.2.206

关键词: Sleep in non-human animalsAnesthesiaNocturnalHypoxemiaArousalpCO2Oxygen saturation (medicine)Chronic bronchitisOxygenationMedicine

摘要: We recorded the electroencephalogram, electrooculogram, electromyogram, and ear oxygen saturation (SaO2) during sleep in 20 patients with chronic bronchitis emphysema, 13 of whom had a low arterial PO2 elevated PCO2 (“blue bloated”) 7 relatively normal (“pink puffing”), compared findings these 9 healthy subjects similar age. All slept for 2 nights there was no difference between groups total period. The lower stable SaO2 than subjects, “blue bloated” having significantly more hypoxemic episodes (p < 0.01). Transient nocturnal hypoxemia commonest REM both its duration not related to any variable examined. shorter periods brief arousal occurring night 0.02). Six representative pat...

参考文章(11)
D. C. Flenley, D. H. Franklin, J. S. Millar, THE HYPOXIC DRIVE TO BREATHING IN CHRONIC BRONCHITIS AND EMPHYSEMA Clinical Science. ,vol. 38, pp. 503- 518 ,(1970) , 10.1042/CS0380503
Eliot A. Phillipson, Colin E. Sullivan, Arousal: The Forgotten Response to Respiratory Stimuli The American review of respiratory disease. ,vol. 118, pp. 807- 809 ,(1978) , 10.1164/ARRD.1978.118.5.807
Alan Stuart, S. Siegel, Non-Parametric Statistics for the Behavioral Sciences. Economica. ,vol. 24, pp. 178- ,(1957) , 10.2307/2551606
Kyung W. Koo, Daniel S. Sax, Gordon L. Snider, Arterial blood gases and pH during sleep in chronic obstructive pulmonary disease The American Journal of Medicine. ,vol. 58, pp. 663- 670 ,(1975) , 10.1016/0002-9343(75)90502-1
H. W. Agnew, Wilse B. Webb, Robert L. Williams, The first night effect: an EEG study of sleep. Psychophysiology. ,vol. 2, pp. 263- 266 ,(1966) , 10.1111/J.1469-8986.1966.TB02650.X
Harman W Agnew, Wilse W Webb, Robert L Williams, Sleep patterns in late middle age males: An EEG study Electroencephalography and Clinical Neurophysiology. ,vol. 23, pp. 168- 171 ,(1967) , 10.1016/0013-4694(67)90107-1
James W. Wynne, A.Jay Block, Judith Hemenway, Lynn A. Hunt, Michael R. Flick, Disordered breathing and oxygen desaturation during sleep in patients with chronic obstructive lung disease (COLD) The American Journal of Medicine. ,vol. 66, pp. 573- 579 ,(1979) , 10.1016/0002-9343(79)91166-5
P M Calverley, D C Flenley, H R Townsend, V Brezinova, The effects of long-term oxygen therapy on the EEG in patients with chronic stable ventilatory failure. Bulletin européen de physiopathologie respiratoire. ,vol. 15, pp. 603- 609 ,(1979)
K P Van de Woestijne, Maurice Demedts, Erik Pillen, Comparative study of EEG changes, clinical encephalopathy and blood gas disturbances in chronic obstructive lung disease. Acta Neurologica Belgica. ,vol. 73, pp. 273- ,(1973)
N.J. Douglas, D.P. White, C.K. Pickett, J.V. Weil, C.W. Zwillich, Hypoxic Ventilatory Response Decreases during Sleep in Man Clinical Science. ,vol. 62, ,(1982) , 10.1042/CS062001PB