NEAr Transporter (NEAT) Domains: Unique Surface Displayed Heme Chaperones That Enable Gram-Positive Bacteria to Capture Heme-Iron From Hemoglobin.

摘要: Iron is an important micronutrient that required by bacteria to proliferate and cause disease. Many bacterial pathogens forage iron from human hemoglobin (Hb) during infections, which contains this metal within heme (iron-protoporphyrin IX). Several clinically pathogenic species the Firmicutes phylum scavenge using surface-displayed or secreted NEAr Transporter (NEAT) domains. In review, we discuss how these versatile proteins function in Staphylococcus aureus Iron-regulated surface determinant system scavenges heme-iron Hb. S. NEAT domains as either Hb receptors heme-binding chaperones. vitro studies have shown can rapidly exchange amongst one another via transiently forming transfer complexes, leading interesting hypothesis they may form a protein-wire peptidoglycan layer through flows microbial membrane. receptors, recent revealed dedicated heme- Hb-binding synergistically extract Hb's molecules, receptor binding Hb-haptoglobin complex block its clearance macrophages, prolonging access iron. The functions of other Gram-positive are also reviewed.