Compositions and methods for eliciting ctl immunity
作者： Howard Grey , Maria A. Vitiello , Robert W. Chesnut , Alessandro D. Sette , Esteban Celis
DOI:
关键词: MHC class I 、 Antigen 、 Immunology 、 Adjuvant 、 Epitope 、 Cytotoxic T cell 、 Immunity 、 Biology 、 Virology 、 CTL* 、 T cell
摘要: Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, CTL-inducing peptide adjuvant or a lipidated which induces helper cell (HTL) response stimulate the specific CTL response. Among viral antigens in humans those hepatitis B. The may be optimized by regimen two more booster administrations. Coktails inducing peptides employed optimize epitope and/or MHC class I restricted coverage.
glgoo.top参考文章(74)
J. Kevin Steele, Julia G. Levy, Anthea T. Stammers, Method to immunize mammals against tumors ,(1987)
Girish N. Vyas, Synthetic vaccine peptide epitomes of hepatitis B surface antigen ,(1980)
H M Grey, G Y Ishioka, S Colon, R W Chesnut, C Miles, Induction of class I MHC-restricted, peptide-specific cytolytic T lymphocytes by peptide priming in vivo. Journal of Immunology. ,vol. 143, pp. 1094- 1100 ,(1989)
L Otvos, E Celis, D Ou, Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides. Journal of Immunology. ,vol. 140, pp. 1808- 1815 ,(1988)
Tetsuo Nakamura, Atsuhiko Machida, Hepatitis B vaccine ,(1985)
Patrizia Pontisso, Alfredo Alberti, M Mondelli, Flavia Bortolotti, G Realdi, R Williams, Eg Rondanelli, Alwf Eddleston, Definition of hepatitis B virus (HBV)-specific target antigens recognized by cytotoxic T cells in acute HBV infection. Clinical and Experimental Immunology. ,vol. 68, pp. 242- 250 ,(1987)
J L Maryanski, G Corradin, C Widmann, P Romero, Differential stability of antigenic MHC class I-restricted synthetic peptides. Journal of Immunology. ,vol. 147, pp. 3745- 3751 ,(1991)
Patrick Charnay, Pierre Tiollais, Francis Galibert, Nucleotidic sequence coding the surface antigen of the hepatitis B virus, vector containing said nucleotidic sequence, process allowing the obtention thereof and antigen obtained thereby ,(1980)
William J. Rutter, Howard M. Goodman, Non-passageable viruses ,(1987)
P Wingfield, J L Hughes, J E Jones, S Stahl, A McLachlan, G B Thornton, D R Milich, Comparative immunogenicity of hepatitis B virus core and E antigens. Journal of Immunology. ,vol. 141, pp. 3617- 3624 ,(1988)