Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat
作者： Sebastian Videla , Jaime Vilaseca , Maria Antolin , Ana Garcia-Lafuente , Francisco Guarner
DOI: 10.1111/J.1572-0241.2001.03802.X
关键词: Internal medicine 、 Inulin 、 Immunology 、 Intracolonic 、 Eicosanoid 、 Medicine 、 Cecum 、 Lesion 、 Enema 、 Butyrate 、 Gastroenterology 、 Colitis
摘要: OBJECTIVES: Inulin stimulates intracolonic generation of butyrate and growth lactic acid bacteria. This study investigated whether inulin protects against colitis. METHODS: Rats with dextran sodium sulfate colitis received either orally (1% in drinking water, or 400 mg/day) by enema. Matched groups vehicle. In addition, fecal water obtained from inulin-fed rats was administered enema to compared control rats. Finally, daily enemas (at 40 80 mmol/L) Inflammation assessed eicosanoid asssay rectal dialysates MPO activity colonic tissue. Mucosal lesions were blindly scored microscopic examination. Luminal pH measured cecum rectum a surface microelectrode. RESULTS: Oral prevented inflammation, as evidenced lower lesion scores (p < 0.05), decreased release mediators tissue 0.05) controls. Inulin induced acidic environment (pH <7.0) left colon increased counts lactobacilli. Fecal also reduced inflammation 0.05). However, had no effect. CONCLUSIONS: Oral reduces the severity colitis. The effect seems be mediated modification milieu.
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