White Matter Degradation is Associated with Reduced Financial Capacity in Mild Cognitive Impairment and Alzheimer’s Disease

摘要: Financial capacity (FC) is a cognitively complex activity of daily living that declines in mild cognitive impairment (MCI) and Alzheimer's disease (AD), limiting an individual's ability to manage one's finances function independently. The neural underpinnings this decline are poorly understood but likely involve age-related disease-related degradation across structural networks. purpose the current study was determine if altered white matter integrity associated with declining FC persons MCI AD compared older controls. Individuals due (n = 31), dementia 39), healthy adults 60) were administered neuropsychological battery including Instrument, performance-based measure FC. All 130 participants also underwent diffusion tensor imaging (DTI) upon which tract-based spatial statistics performed. Both decreased accordance severity little no effect elderly, significant effects MCI, greater AD. Regional (increased diffusivities fractional anisotropy) reduced both groups even after controlling for age, education, gender. Specifically, anisotropy, not increased diffusivities, poorer widespread cingulo-parietal-frontal temporo-occipital areas. In AD, rather than mean axial anterior cingulate, callosum, frontal areas These findings suggest gradient DTI metrics stages predict financial skill knowledge.