Device and apparatus

作者: Philip Wakeley , Graham Gutsell

DOI:

关键词: MembraneNucleic acidAnalytical chemistryChemistryLiquid phaseChromatography

摘要: A device (1) for carrying out a chemical or biochemical reaction and detecting the results, such as an assay to detect target nucleic acid in sample, said comprising (i) first well (8) which amplification may be effected liquid phase receiving means well; (ii) channel (16) extending from (iii) lateral flow (32) arranged receive contents channel, optionally by way of second well, on bibulous membrane thereon, wherein contains elements that are able products acid. Methods using devices apparatus assays these also described claimed.

参考文章(38)
Timothy Allan Brown, Timothy Chow, Lateral flow PCR with amplicon concentration and detection ,(2001)
Cecile Paris, Brian Kluttz, Lawrence Burg, Louis Graziano, Robert Glassfield, Luigi Catanzariti, Garry Tegeler, Geoff A. Mckinley, James Greer, James Clement Bishop, Thomas Wang, Christopher Cotter, Michael Morin, Michel Guy, Bruno Colin, Disposable test devices for performing nucleic acid amplification reactions ,(2000)
Douglas B. Dority, Farzad Pourahmadi, Ronald Chang, Michael T. Taylor, Phillip Belgrader, William A. McMillan, Apparatus and method for rapid ultrasonic disruption of cells or viruses ,(1999)
Roy R. Mondesire, John C. Gerdes, Lara A. Hansen, Lateral flow system for nucleic acid detection ,(2004)
Dafeng Chen, Michael Mauk, Xianbo Qiu, Changchun Liu, Jitae Kim, Sudhir Ramprasad, Serge Ongagna, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens, Haim H. Bau, An integrated, self-contained microfluidic cassette for isolation, amplification, and detection of nucleic acids Biomedical Microdevices. ,vol. 12, pp. 705- 719 ,(2010) , 10.1007/S10544-010-9423-4
W. R ABRAMS, C. A BARBER, K. MCCANN, G. TONG, Z. CHEN, M. G MAUK, J. WANG, A. VOLKOV, P. BOURDELLE, P. L. A. M CORSTJENS, M. ZUIDERWIJK, K. KARDOS, S. LI, H. J TANKE, R SAM NIEDBALA, D. MALAMUD, H. BAU, Development of a Microfluidic Device for Detection of Pathogens in Oral Samples Using Upconverting Phosphor Technology (UPT) Annals of the New York Academy of Sciences. ,vol. 1098, pp. 375- 388 ,(2007) , 10.1196/ANNALS.1384.020
Z. CHEN, M. G MAUK, J. WANG, W. R ABRAMS, P. L. A. M CORSTJENS, R. S. NIEDBALA, D. MALAMUD, H. H BAU, A Microfluidic System for Saliva-Based Detection of Infectious Diseases Annals of the New York Academy of Sciences. ,vol. 1098, pp. 429- 436 ,(2007) , 10.1196/ANNALS.1384.024
Jing Wang, Zongyuan Chen, Paul L. A. M. Corstjens, Michael G. Mauk, Haim H. Bau, A disposable microfluidic cassette for DNA amplification and detection Lab on a Chip. ,vol. 6, pp. 46- 53 ,(2006) , 10.1039/B511494B