Hantzsch-Type Dihydropyridines and Biginelli-Type Tetra-hydropyrimidines: A Review of their Chemotherapeutic Activities
作者： Saghi Sepehri , Horacio Perez Sanchez , Afshin Fassihi
DOI: 10.18433/J3Q01V
关键词: Bioinformatics 、 Pharmacology 、 Medicine
摘要: Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4-tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. This is mainly due to convenient methods that exist for their synthesis diverse pharmacologic properties these scaffolds present. 1,4-Dihydropyridines usually regarded analogous in several aspects. They both prepared multi-component reactions using very similar starting materials protocols. leads common structural features between 1,4-DHPs 1,2,3,4-THPMs, well related biological effects. For example, they share many pharmacological such analgesic, anti-tumor, antioxidant, anti-inflammatory, antitubercular, antibacterial, cardiovascular adrenoceptor blocking activities. Numerous reviews have been devoted chemistry effects of compounds. However, lack a comprehensive literature overview chemotherapeutic ability scaffolds behind present attempt provide detailed survey 1,2,3,4-THPMs article open POST-PUBLICATION REVIEW . Registered readers (see “For Readers”) may comment by clicking ABSTRACT issue’s contents page.
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