Thromboelastography (TEG) Cups and Pins with Different PECVD Coatings: Effect on the Coagulation Cascade in Platelet‐poor Blood Plasma
作者： Angel Contreras-García , Yahye Merhi , Juan-Carlos Ruiz , Michael R. Wertheimer , Caroline D. Hoemann
关键词: Thromboelastography 、 Chemical engineering 、 Platelet 、 Plasma polymerization 、 Wetting 、 Blood proteins 、 Blood plasma 、 Chemistry 、 Fibrin 、 Clotting time 、 Polymer chemistry
摘要: Thromboelastography uses cups and pins made of Cyrolite ® plastic to analyze the rate fibrin clot formation in blood samples. In this study, TEG were modified by 4 distinct coating types using plasma-enhanced chemical vapor deposition (PECVD): carboxylated, amine-rich, hydrophobic, SiO 2 , analyzed for surface chemistry wettability. We tested hypothesis that coagulation kinetics recalcified citrated plasma is controlled chemistry, absence activator. Only carboxylated surfaces became negatively charged upon wetting, accelerated a highly reproducible manner, whereas other coatings had delayed unpredictable clotting times. These data are consistent with model whereby selectively adsorb activate factor XII while repelling more abundant anionic proteins, resulting kinetics.
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