Amide-Type Adduct of Dopamine – Plausible Cause of Parkinson Diseases

摘要: Dopamine is the endogenous neurotransmitter produced by nigral neurons. loss can trigger not only prominent secondary morphological changes, but also changes in density and sensitivity of dopamine receptors; therefore, it a sign PD development. The reasons for are attributed to dopamine’s molecular instability due member catecholamine family, whose catechol structure contributes high oxidative stress through enzymatic non-enzymatic oxidation. Oxidative brain easily leads lipid peroxidation reaction concentration polyunsaturated fatty acids (PUFA), such as docosahexaenoic acid (DHA, C22:6/ω-3) arachidonic (AA, C18:4/ω-6). Recent studies have shown that hydroperoxides, primary peroxidative products, could non-specifically react with amino groups form N-acyl-type (amide-linkage) adducts. Therefore, based on NH2-teminals structure, aims this chapter describes possibility reactive LOOH species derived from DHA/AA may modify amide-linkage adducts, which might be related etiology Parkinson’s diseases.