Model for end-stage liver disease (MELD) exception for unusual metabolic liver diseases

摘要: Metabolic liver disease is the underlying diagnosis in only a small proportion of patients who undergo transplantation (LT), but for these patients, LT lifesaving. Patients with metabolic often do not present typical findings end-stage and require special consideration scrutiny concerning appropriateness timing LT. Liverbased classified into 3 types: (1) that causes structural damage failure or cirrhosis, (2) without affects other organs (especially central nervous system), (3) systemic deficiencies are partially represented liver. There may be overlap presentation, some forms presenting either disease. General considerations affect review board decisions include relative contraindication use living-related donor unpredictable course cause severe system complications several states. Also, although many diseases mostly children, adolescents adults previously managed medically increasingly when medical management becomes more difficult complex as they mature.