The effect of contact line pinning favors the mass production of monodisperse microbubbles

摘要: A robust method for the generation of phospholipid-covered monodisperse microbubbles diameters smaller than 10 μm at production rates larger 105 Hz is presented here. We show that bubbles are periodically formed from tip a long and thin gas ligament stabilized thanks to both strong favorable pressure gradient existing entrance region rectangular PDMS–PDMS channel pinning gas–liquid interface centered groove several microns' width placed on one its walls. Moreover, exit incorporated in our design favors transport phospholipid molecules toward interface. Our experiments resulting shell inhibits diffusion surrounding liquid coalescence between contacting bubbles. These evidences indicate proposed suitable diagnosis or therapeutical applications.