Interspecies Constancy of N-Terminal Amino-acid Sequences in the γ-Chain of Fibrinogen

作者: HUBERT PIRKLE , AGNES HENSCHEN , AIJA POTAPOUS

DOI: 10.1038/223400A0

关键词: FibrinogenBiochemistryPeptideSequence (biology)Protein primary structureAmino acidMoleculeDisulphide bondsBiology

摘要: THE fibrinogen molecule from several mammals is made up of three different peptide chains1,2, the α(A), β(B) and γ chains, which are cross-linked by disulphide bonds possibly other bonds3–6. Previous comparative studies primary structure have dealt with its N-terminal amino-acids2 amino-acid sequences fibrinopeptides A B, released amino termini respective chains action thrombin7. These shown considerable interspecies variation in fibrinopeptides, except for a relatively constant C-terminal sequence fibrino-peptide A. We now report second molecule, terminus γ-chain.

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