Visualization of nasal airflow patterns in a patient affected with atrophic rhinitis using particle image velocimetry

作者: G J M Garcia , G Mitchell , N Bailie , D Thornhill , J Watterson

DOI: 10.1088/1742-6596/85/1/012032

关键词: PathologyBiomedical engineeringNoseBreathingMucosal drynessNasal congestionMedicineNasal airflowPatient affectedParticle image velocimetryNasal cavity

摘要: The relationship between airflow patterns in the nasal cavity and function is poorly understood. This paper reports an experimental study of interplay symptoms a patient affected with atrophic rhinitis. pathology characterized by mucosal dryness, fetor, progressive atrophy anatomical structures, spacious cavity, paradoxical sensation congestion. A physical replica patient's geometry was made particle image velocimetry (PIV) used to visualize measure flow field. based on computed tomography (CT) scans built three steps: three-dimensional reconstruction CT scans; rapid prototyping cast; sacrificial use cast form model passage clear silicone. Flow were measured running water-glycerol mixture through evaluating displacement particles dispersed liquid using PIV. rate corresponded air representative human breathing at rest. trajectory observed left nose (more rhinitis) differed markedly from what considered normal, consistent epithelial damage cases condition. data are also useful for validation computational fluid dynamics predictions.

参考文章(12)
Eric J. Moore, Eugene B. Kern, Atrophic Rhinitis: A Review of 242 Cases: American Journal of Rhinology. ,vol. 15, pp. 355- 361 ,(2001) , 10.1177/194589240101500601
S Schreck, KJ Sullivan, CM Ho, HK Chang, None, Correlations between flow resistance and geometry in a model of the human nose. Journal of Applied Physiology. ,vol. 75, pp. 1767- 1775 ,(1993) , 10.1152/JAPPL.1993.75.4.1767
Ravi.P. Subramaniam, Regina.B. Richardson, Kevin.T. Morgan, Julia.S. Kimbell, Raymond.A. Guilmette, COMPUTATIONAL FLUID DYNAMICS SIMULATIONS OF INSPIRATORY AIRFLOW IN THE HUMAN NOSE AND NASOPHARYNX Inhalation Toxicology. ,vol. 10, pp. 91- 120 ,(1998) , 10.1080/089583798197772
I. Hahn, P. W. Scherer, M. M. Mozell, Velocity profiles measured for airflow through a large-scale model of the human nasal cavity Journal of Applied Physiology. ,vol. 75, pp. 2273- 2287 ,(1993) , 10.1152/JAPPL.1993.75.5.2273
Sunil Narayan Dutt, Mohan Kameswaran, None, The aetiology and management of atrophic rhinitis The Journal of Laryngology & Otology. ,vol. 119, pp. 843- 852 ,(2005) , 10.1258/002221505774783377
Experimental determination of the kinematic viscosity of glycerol-water mixtures Proceedings of The Royal Society A: Mathematical, Physical and Engineering Sciences. ,vol. 444, pp. 573- 581 ,(1994) , 10.1098/RSPA.1994.0039
Michael Wolf, Sara Naftali, Robert C. Schroter, David Elad, Air-conditioning characteristics of the human nose The Journal of Laryngology & Otology. ,vol. 118, pp. 87- 92 ,(2004) , 10.1258/002221504772784504
Guilherme J. M. Garcia, Neil Bailie, Dário A. Martins, Julia S. Kimbell, Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. Journal of Applied Physiology. ,vol. 103, pp. 1082- 1092 ,(2007) , 10.1152/JAPPLPHYSIOL.01118.2006
K. Keyhani, P. W. Scherer, M. M. Mozell, Numerical simulation of airflow in the human nasal cavity. Journal of Biomechanical Engineering-transactions of The Asme. ,vol. 117, pp. 429- 441 ,(1995) , 10.1115/1.2794204
L. M. Hopkins, J. T. Kelly, A. S. Wexler, A. K. Prasad, Particle image velocimetry measurements in complex geometries Experiments in Fluids. ,vol. 29, pp. 91- 95 ,(2000) , 10.1007/S003480050430