Shedding the load of hypertension: The proteolytic processing of angiotensin-converting enzyme
作者： Mario R W Ehlers , Kerry Gordon , Sylva L U Schwager , Edward D Sturrock
DOI: 10.7196/SAMJ.5596
关键词: ADAM Proteins 、 Matrix metalloproteinase 、 Cell biology 、 Cell 、 Mechanism (biology) 、 Sheddase 、 Medicine 、 Immunology 、 Angiotensin-converting enzyme 、 Enzyme 、 Membrane protein
摘要: A number of membrane proteins are enzymatically cleaved or 'shed' from the cell surface, resulting in modulation biological events and opening novel pharmaceutical approaches to diverse diseases by targeting shedding. Our focus has been on understanding shedding angiotensin-converting enzyme (ACE), an that plays a pivotal role blood pressure regulation. The identification hereditary ACE mutations result increased advanced our health disease. Extensive biochemical molecular analysis helped elucidate mechanism These findings point potential therapeutic regulating tissue levels cardiovascular
sci-hub.se 参考文章(18)
Victor J Dzau, Kenneth Bernstein, David Celermajer, Jerome Cohen, Björn Dahlöf, John Deanfield, Javier Diez, Helmut Drexler, Roberto Ferrari, Wiek Van Gilst, Lennart Hansson, Burkhard Hornig, Ahsan Husain, Colin Johnston, Harold Lazar, Eva Lonn, Thomas Lüscher, John Mancini, Albert Mimran, Carl Pepine, Ton Rabelink, Willem Remme, Luis Ruilope, Marcel Ruzicka, Heribert Schunkert, Karl Swedberg, Thomas Unger, Douglas Vaughan, Michael Weber, None, Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. Cardiovascular Drugs and Therapy. ,vol. 16, pp. 149- 160 ,(2002) , 10.1023/A:1015709617405
K. Ravi Acharya, Edward D. Sturrock, James F. Riordan, Mario R. W. Ehlers, ACE revisited: A new target for structure-based drug design Nature Reviews Drug Discovery. ,vol. 2, pp. 891- 902 ,(2003) , 10.1038/NRD1227
Mario R. W. Ehlers, James F. Riordan, Angiotensin-converting enzyme: new concepts concerning its biological role Biochemistry. ,vol. 28, pp. 5311- 5318 ,(1989) , 10.1021/BI00439A001
Christophe Bonnefoy, Marie-Thérèse Chauvet, Pierre Corvol, Véronique Beldent, Annie Michaud, Cell Surface Localization of Proteolysis of Human Endothelial Angiotensin I-converting Enzyme: EFFECT OF THE AMINO-TERMINAL DOMAIN IN THE SOLUBILIZATION PROCESS Journal of Biological Chemistry. ,vol. 270, pp. 28962- 28969 ,(1995) , 10.1074/JBC.270.48.28962
Tobias M. J. Allinson, Edward T. Parkin, Thomas P. Condon, Sylva L. U. Schwager, Edward D. Sturrock, Anthony J. Turner, Nigel M. Hooper, The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein FEBS Journal. ,vol. 271, pp. 2539- 2547 ,(2004) , 10.1111/J.1432-1033.2004.04184.X
Zenda L. Woodman, Sylva L. U. Schwager, Pierre Redelinghuys, Adriana K. Carmona, Mario R. W. Ehlers, Edward D. Sturrock, The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity. Biochemical Journal. ,vol. 389, pp. 739- 744 ,(2005) , 10.1042/BJ20050187
Mario R. W. Ehlers, Sylva L. U. Schwager, Renate R. Scholle, Gulam A. Manji, Wolf F. Brandt, James F. Riordan, Proteolytic Release of Membrane-Bound Angiotensin-Converting Enzyme: Role of the Juxtamembrane Stalk Sequence† Biochemistry. ,vol. 35, pp. 9549- 9559 ,(1996) , 10.1021/BI9602425
Mario R. W. Ehlers, James F. Riordan, Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins Biochemistry. ,vol. 30, pp. 10065- 10074 ,(1991) , 10.1021/BI00106A001
Paul Saftig, Karina Reiss, The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential? European Journal of Cell Biology. ,vol. 90, pp. 527- 535 ,(2011) , 10.1016/J.EJCB.2010.11.005
Mario R. W. Ehlers, James F. Riordan, Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes. Biochemistry. ,vol. 30, pp. 7118- 7126 ,(1991) , 10.1021/BI00243A012