Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform
作者： Michael D. Shultz , James C. Duchamp , John D. Wilson , Chun-Ying Shu , Jiechao Ge
DOI: 10.1021/JA9093617
关键词: Conjugated system 、 Peptide 、 Interleukin 13 、 Metallofullerene 、 Encapsulation (networking) 、 Cage 、 Nanoparticle 、 Chemistry 、 Nanotechnology 、 Combinatorial chemistry 、 Fullerene
摘要: In this communication, we describe the successful encapsulation of 177Lu into endohedral metallofullerene 177LuxLu3−xN@C80 (x = 1−3) starting with 177LuCl3 in a modified quartz Kraschmer−Huffman electric generator. We demonstrate that (β-emitter) fullerene cage is not significantly released for period up to at least one-half-life (6.7 days). also agent can be conjugated an interleukin-13 peptide designed target overexpressed receptor glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility wide range radiotherapeutic and radiodiagnostic multimodal applications.
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