Polycythemia is associated with bone loss and reduced osteoblast activity in mice
作者： P. R. Oikonomidou , C. Casu , Z. Yang , B. Crielaard , J. H. Shim
DOI: 10.1007/S00198-015-3412-7
关键词: Recombinant EPO 、 Immunology 、 Phenotype 、 Polycythemia vera 、 Bone remodeling 、 Rheumatology 、 Erythropoietin 、 Internal medicine 、 Medicine 、 Bone density 、 Osteoblast 、 Endocrinology
摘要: Summary Increased fragility has been described in humans with polycythemia vera (PV). Herein, we describe an osteoporotic phenotype associated decreased osteoblast activity a mouse model of PV and another elevated circulating erythropoietin (EPO). Our results are important for patients or those treated recombinant EPO (rEPO).
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