Subclinical Organ Damage in White-Coat Hypertension: The Possible Role of Cystatin C
作者： Emmanuel Androulakis , Nikolaos Papageorgiou , Eirini Lioudaki , Evaggelos Chatzistamatiou , Effimia Zacharia
DOI: 10.1111/JCH.12882
关键词: Medicine 、 Pulse wave velocity 、 Cystatin C 、 White coat hypertension 、 Organ damage 、 Internal medicine 、 Endocrinology 、 Left ventricular hypertrophy 、 Left ventricular mass 、 Cardiology 、 Subclinical infection
摘要: The authors investigated the relationship of white-coat hypertension (WCH) with subclinical organ damage and potential relevant mechanisms. A total 386 untreated patients were enrolled divided into 204 WCH 183 normotension. Flow-mediated dilation (FMD), pulse wave velocity (PWV), intima-media thickness, left ventricular mass index (LVMI), cystatin C levels measured. All tests two-sided, a P value <.05 was considered statistically significant. group exhibited higher LVMI PWV values, decreased E/A ratio FMD increased prevalence for hypertrophy compared controls (P<.001 all). Cystatin significantly in (P=.035) positively associated (P<.05 both). presence is more pronounced may play significant role therefore warrants further investigation.
sci-hub.se 参考文章(49)
H Yavuzer, M Cengiz, S Yavuzer, M Rıza Altıparmak, B Korkmazer, H Balci, A L Yaldıran, H Uzun, Procalcitonin and Pentraxin-3: Current biomarkers in inflammation in white coat hypertension Journal of Human Hypertension. ,vol. 30, pp. 424- 429 ,(2016) , 10.1038/JHH.2015.59
Carmen A. Peralta, David R. Jacobs, Ronit Katz, Joachim H. Ix, Magdalena Madero, Daniel A. Duprez, Mark J. Sarnak, Michael H. Criqui, Holly J. Kramer, Walter Palmas, David Herrington, Michael G. Shlipak, Association of Pulse Pressure, Arterial Elasticity, and Endothelial Function With Kidney Function Decline Among Adults With Estimated GFR >60 mL/min/1.73 m2: The Multi-Ethnic Study of Atherosclerosis (MESA) American Journal of Kidney Diseases. ,vol. 59, pp. 41- 49 ,(2012) , 10.1053/J.AJKD.2011.08.015
Sang-Hyun Ihm, Ho-Joong Youn, Chan-Seok Park, Hee-Yeol Kim, Kiyuk Chang, Ki-Bae Seung, Jae-Hyung Kim, Kyu-Bo Choi, Target Organ Status in White-Coat Hypertensives : Usefulness of Serum Procollagen Type I Propeptide in the Respect of Left Ventricular Diastolic Dysfunction Japanese Circulation Journal-english Edition. ,vol. 73, pp. 100- 105 ,(2009) , 10.1253/CIRCJ.CJ-08-0464
Keiko Nakai, Masayuki Kikuchi, Keiko Fujimoto, Yoshito Kaneko, So Omori, Kenji Nakai, Akira Suwabe, Serum levels of cystatin C in patients with malignancy. Clinical and Experimental Nephrology. ,vol. 12, pp. 132- 139 ,(2008) , 10.1007/S10157-008-0043-8
Ioannis Andrikou, Costas Tsioufis, Kyriakos Dimitriadis, Dimitris Syrseloudis, Panagiota Valenti, Mariota Almiroudi, Louiza Lioni, Dimitris Tousoulis, Christodoulos Stefanadis, Similar levels of low-grade inflammation and arterial stiffness in masked and white-coat hypertension: comparisons with sustained hypertension and normotension. Blood Pressure Monitoring. ,vol. 16, pp. 218- 223 ,(2011) , 10.1097/MBP.0B013E32834AF710
Sante D Pierdomenico, Francesco Cipollone, Domenico Lapenna, Anna Bucci, Franco Cuccurullo, Andrea Mezzetti, Endothelial function in sustained and white coat hypertension American Journal of Hypertension. ,vol. 15, pp. 946- 952 ,(2002) , 10.1016/S0895-7061(02)02993-X
Wolfgang Koenig, Dorothee Twardella, Hermann Brenner, Dietrich Rothenbacher, Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate. Clinical Chemistry. ,vol. 51, pp. 321- 327 ,(2005) , 10.1373/CLINCHEM.2004.041889
R B Devereux, N Reichek, Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation. ,vol. 55, pp. 613- 618 ,(1977) , 10.1161/01.CIR.55.4.613
M. W Muscholl, H.-W Hense, U. Brockel, A. Doring, G. A J Riegger, H. Schunkert, Changes in left ventricular structure and function in patients with white coat hypertension: cross sectional survey BMJ. ,vol. 317, pp. 565- 570 ,(1998) , 10.1136/BMJ.317.7158.565
Emmanuel S. Androulakis, Dimitris Tousoulis, Nikolaos Papageorgiou, Costas Tsioufis, Ioannis Kallikazaros, Christodoulos Stefanadis, Essential hypertension: is there a role for inflammatory mechanisms? Cardiology in Review. ,vol. 17, pp. 216- 221 ,(2009) , 10.1097/CRD.0B013E3181B18E03