Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture

摘要: During the pathogenesis of coronary atherosclerosis, from lesion initiation to rupture, arterial mechanical properties are altered by a number cellular, molecular, and hemodynamic processes. There is growing recognition that factors may actively drive vascular cell signaling regulate atherosclerosis disease progression. In advanced plaques, atheroma influence stress distributions in fibrous cap mediate plaque rupture resulting acute events. This review paper explores current optical technologies provide information on tissue advance our understanding involved development leading rupture. The approaches discussed include microrheology traction force microscopy probe behavior single extracellular matrix components, intravascular imaging modalities including laser speckle rheology, coherence elastography, polarization-sensitive tomography measure lesions. Given wealth these techniques can provide, poised play an increasingly significant role elucidating aspects future.