Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.
作者： A M Zeiher , H Drexler , H Wollschläger , H Just
关键词: Internal medicine 、 Endothelial dysfunction 、 Vascular resistance 、 Blood flow 、 Anterior Descending Coronary Artery 、 Medicine 、 Vascular smooth muscle 、 Cold pressor test 、 Cardiology 、 Endothelium 、 Vasodilation
摘要: BACKGROUNDThe vascular endothelium is capable of regulating tissue perfusion by the release endothelium-derived relaxing factor to modulate vasomotor tone resistance vasculature.METHODS AND RESULTSTo test whether atherosclerosis associated with a functional abnormality endothelium-mediated microvascular relaxation affecting coronary blood flow regulation, we compared responses cold pressor testing response vasculature acetylcholine (an endothelium-dependent vasodilator) and papaverin (a direct dilator smooth muscle) in 12 normal control patients 19 non-flow-limiting epicardial (CAD). The drugs were subselectively infused into left anterior descending artery via Doppler catheter, was assessed measuring intracoronary velocity cross-sectional arterial area (quantitative angiography). Coronary decre...
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