Evaluation of short-term tests for carcinogenicity

摘要: Abstract Current bioassays to assess the carcinogenicity of environmental agents involve cumbersome and lengthy studies in animals. Thus, detection potential carcinogens would benefit by development rapid yet reliable tests for carcinogens. Tests proposed detecting carcinogenic activity include prescreening chemicals for: (1) accelerated tumor formation, (2) chromosome aberrations, (3) mutagenesis, (4) DNA repair synthesis, (5) teratogenesis, (6) vitro cell transformation, (7) reaction with nucleic acids (8) cytological alterations. Each these test systems was critically evaluated respect its possible relevance process practicality. Three tests, synthesis transformation were found offer considerable promise as prescreens chemical So far they correlate well agent under test, especially when metabolic activation a reactive species effected.