Side chain functionality dominated the chromatography of N-protected amino acid on molecularly imprinted polymer
作者： Yu-Chi Lin , Hsin-Hung Pan , Ching-Chiang Hwang , Wen-Chien Lee
DOI: 10.1002/APP.26621
关键词: Radical polymerization 、 Amino acid 、 High-performance liquid chromatography 、 Pyridine 、 Molecularly imprinted polymer 、 Photopolymer 、 Molecular imprinting 、 Chemistry 、 Chromatography 、 Side chain
摘要: Molecularly imprinted polymer (MIP) with Nα-protected amino acid as the print molecule was prepared and used stationary phase for chromatographic study of molecular recognition. Particles MIP were by photopolymerization 4-vinylpyridine in presence tert-butyloxycarbonyl-L-tyrosine (Boc-L-Tyr) packed into a column resolution Boc-L-Tyr tert-butyloxycarbonyl-L-phenylalanine (Boc-L-Phe). These two acids that differ from each other side chain one hydroxyl group on benzene ring could be well separated MIP. A separation factor about achieved using mixture acetonitrile (99.5 v/v %) acetic (0.5 mobile phase. Results suggest interaction between pyridine dominated selective adsorption © 2007 Wiley Periodicals, Inc. J Appl Polym Sci,
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