First-line therapy with doxycycline in ocular adnexal mucosa-associated lymphoid tissue lymphoma: a retrospective analysis of clinical predictors.

摘要: This retrospective study was launched to evaluate the efficacy of doxycycline and find independent predictors a clinical response in patients with ocular adnexal lymphoma mucosa-associated lymphoid tissue (OAML). Thirty-eight newly diagnosed, localized OAML received for 3 weeks (12 patients) or 6 weeks (26 patients). Clinical factors including absolute lymphocyte count (ALC) neutrophil (ANC) were compared between responders non-responders. After median follow-up 26.4 months, resulted an overall rate 47% 3-year time-to-treatment failure (TTF) 84%. Patients treated versus tended have higher (54%vs 33%). Absolute lymphocytosis (ALC > 3.01 × 109/L) neutrophilia (ANC > 1.92 × 109/L) defined based on value each count. (19 without had significantly shorter 2-year TTF (70%vs 100%, P = 0.021) lower (32%vs 63%, P = 0.051). (odds ratio [OR] = 4.7; 95% confidence interval [CI], 1.1–20.8; P = 0.043) non-conjunctival tumor (OR = 11.8; CI, 1.1–122.5; P = 0.038) negative by multivariate analysis. Front-line is effective particularly but conjunctival involvement. (Cancer Sci 2010; 101: 1199–1203)