作者: Dale Han , Daniel C Thomas , Jonathan S Zager , Barbara Pockaj , Richard L White
关键词: Melanoma 、 Surgery 、 Metastasis 、 Medicine 、 Randomized controlled trial 、 Lymphadenectomy 、 Internal medicine 、 Oncology 、 Lymph 、 Biopsy 、 Sentinel lymph node 、 Wide local excision
摘要: An estimated 73870 people will be diagnosed with melanoma in the United States 2015, resulting 9940 deaths. The majority of patients cutaneous melanomas are cured wide local excision. However, current evidence supports use sentinel lymph node biopsy (SLNB) given 15%-20% who harbor regional metastasis. More importantly, presence or absence nodal micrometastases has been found to most important prognostic factor early-stage melanoma, particularly intermediate thickness melanoma. This review examines development SLNB for as a means determine patient's status, efficacy and biology metastatic nodes. Prospective randomized trials have guided practice guidelines shown value SLNB. Given rapidly advancing molecular surgical technologies, technical aspects diagnosis, identification, management nodes continues evolve improve. Additionally, there is ongoing research examining both role specific clinical scenarios ways identify may benefit from completion lymphadenectomy positive SLN. Until further data provides sufficient alter national consensus-based guidelines, remains standard care clinically node-negative